Quarles, the Cavaliers' lone senior starter and leading scorer, was given a breather with 5:15 left in the first half and the Tar Heels clinging to a 29-27 lead.
She returned two minutes later to a game only vaguely resembling the one she left. Without Quarles, who scored four of the last eight UVa. points before she exited, UNC regained its momentum.
The Tar Heels scored five straight points after UVa. tied the game at 29. UNC would go on to score six more when she returned to end the half on an 11-0 run
"I just felt like it was a good time to give her a blow and help her to rest a little bit, but it was just too long," said Virginia coach Debbie Ryan.
Quarles' importance was evident in the second half, when she nearly brought her team back into the game by herself.
LaTonya Blue tallied the first second-half basket for UVa., but for the next 10 points, the Cavalier offense was 100 percent Quarles.
Quarles started with a step-back three-pointer off a screen by teammate Lynette O'Reggio. She soon would add another trifecta, scoring from the right side.
Quarles went on to hit the next two baskets for the Cavaliers, one on a backdoor layup, the other on a fadeaway. Quarles attributed the outburst not to the rest she got at halftime but rather to changes in offensive strategy made during the break.
"Coach decided to let Anna Prillaman run the (point) a little bit to see if I could get my shot going," Quarles said.