The Associated Press reported Thursday that Helms told hundreds of people at the "Prescription for Hope" conference, held by Samaritan's Purse, in Washington, D.C. this week that he regrets not exerting more effort against the worldwide epidemic.
"I have been too lax too long in doing something really significant about AIDS," Helms said, according to the AP. "I'm not going to lay it aside on my agenda for the remaining months I have (in office)."
Helms, who is nearing the end of his fifth term in office, is notorious for his opposition to gay rights and AIDS and HIV research.
Helms said he turned to Franklin Graham, chief executive officer of Samaritan's Purse, for guidance on how to deal with the AIDS epidemic in Africa.
Several AIDS activists said they are pleased that Helms intends to do more to fight the deadly disease.
Patsy Clarke, who lost her son, Mark, to AIDS, wrote a plea to Helms in 1994, trying to convince him to cease his opposition to AIDS research.
After receiving a reply from Helms stating that he was unwilling to change his stance on homosexuality and AIDS, Clarke co-founded Mothers Against Jesse in Congress.
Clarke said she was not angry at Helms for his response, but found Helms' stand on AIDS unsettling.
"I was disturbed that such a view could exist in someone so powerful," she said.