During his hourlong lecture, the former speech writer for President Richard Nixon primarily discussed the crisis in the Middle East. He also made comments about officials in the Bush administration and Iraqi leader Saddam Hussein.
Calling Israeli Prime Minister Ariel Sharon a friend, Safire laid blame for the problems in the region on Palestinian leader Yasser Arafat and defended Sharon against charges that the prime minister has been the instigator.
"With Sharon, you have a man who all his life has been demonized," Safire said. "He's not a demon -- he's a good man."
Safire related Israel's actions to the American retaliation to the terrorist attacks of Sept. 11, saying the recent spate of Palestinian suicide bombings has forced Israel to defend itself.
He said past attempts by American presidents to be a third-party mediator in the ongoing dispute have failed, mentioning a meeting between former President Bill Clinton, former Israeli Prime Minister Ehud Barak and Arafat in July 2000. The three parties failed to work out a peace deal at the gathering.
An interesting aspect of the situation, Safire said, is the reaction he has noticed from American politicians.
Democrats, who traditionally receive the majority of American Jewish votes, have been vocal in encouraging Bush to be remain neutral, he said. Republicans have been more critical of the Palestinians, stressing the importance of keeping Israel as an ally.
"Go figure," Safire said.
Safire discussed criticism he has received from other journalists who have said he is Sharon's mouthpiece; Safire has quoted the prime minister in his columns for The New York Times.