Sen. Fountain Odom, D-Mecklenburg, is in just such a situation as he battles Republican challenger Robert Pittenger.
"It pits the Republican quest for a majority in the Senate with the Democrats trying to defend and maintain one of their leaders," said Ferrel Guillory, director of UNC's Program on Southern Politics, Media and Public Life.
Democrats have controlled the Senate for more than a century, but many political pundits say that as a result of redrawn districts, Republicans might gain control.
Guillory said the Odom-Pittenger race is a prime example of new district lines' effects.
Republicans recognize this as one of their key races, said N.C. Senate Minority Leader Patrick Ballantine, R-New Hanover. "You have to win those races if you want to be in the majority," he said.
But Democrats say they are confident they will retain a majority in the Senate.
"Regardless of what happens, we will keep power," said N.C. Senate Majority Leader Tony Rand, D-Cumberland.
Though victory is not as certain as in previous years, Odom says he expects to be re-elected. "We're confident, but we're not taking anything for granted," he said.
Odom said he is going door-to-door, campaigning much as he has in the past.