Wake's first score came in the 12th minute when sophomore Kelly Dostal batted a pass from junior Kelly Doton past UNC goalkeeper Amy Tran.
The Deacs got their second goal in the 61st minute when senior Heather Aughinbaugh scored an unassisted tally.
Wake Forest had 15 shots to the Tar Heels' 14, but the UNC had four more penalty corners (11) than Wake (7).
The win was Wake's 12th consecutive and its 21st in a row at Kentner Stadium.
Wake has beaten the Tar Heels in the last five meetings, including a 2-1 win earlier this season in Chapel Hill. That game, on Sept. 29, was the season's designated ACC matchup.
On Saturday, the Tar Heels celebrated Senior Day at Henry Stadium by defeating Duke 3-1.
UNC started the day by honoring its three seniors -- Stephanie Fuller, Meredith Keller and Tran -- and their parents at midfield before start of the game.
Tied 1-1 in the second half, UNC's Laura Douglas scored her second goal of the game, and Alison Stewart sealed the win with a goal of her own in the 63rd minute, giving the three seniors a victory in their final home game of their Tar Heel careers.
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